Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria

Figure 6

Fingerprint of NTD for the JFCR39 panel. Fingerprint indicates the differential growth inhibition pattern of NTD for the cell lines in the JFCR39 panel. The -axis (solid bar) shows difference in logarithmic scale between the mean of log GI₅₀ values for all 39 cell lines (MG–MID, expressed as 0 in the fingerprint) and the log GI₅₀ (μM) for each cell line in JFCR39 panel. Columns to the right of 0 indicate the sensitivity of the cell lines to a given compound and columns to the left indicate the resistance. MG–MID, mean of log GI₅₀ values for all 39 cell lines; Delta, difference between the MG–MID and the log GI₅₀ value for the most sensitive cell line; Range, difference between the log GI₅₀ values for the most resistant cell line and the most sensitive cell line.