BioMed Research International / 2017 / Article / Tab 3

Research Article

Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Table 3

Inhibition zones antibiotics (distance (mm) between test disk and bacterial growth).

Strain GM (µg/disc)Only GM Fosfomycin (µg/disc)Daptomycin (µg/disc)
3.97.815.631.225.97.823.4

S. aureus ATCC 2921300046756.57.58.5
263.54n.d.n.d.4.55n.d.n.d.
7.88.5n.d.n.d.67n.d.n.d.5.56.5

S. aureus ATCC 43300000004.55.56.57.58.5
2000n.d.n.d.12n.d.n.d.
7.80n.d.n.d.12n.d.n.d.2.54.5

S. epidermidis DSM 89130057.51013.577.5910
2013.515.5n.d.n.d.4.57n.d.n.d.
7.80n.d.n.d.19.522n.d.n.d.78

E. faecium DSM 13590000012.53456.5
2008n.d.n.d.04n.d.n.d.
7.81n.d.n.d.010n.d.n.d.25

E. coli DSM 223110068.59.512n.d.n.d.n.d.n.d.
2634n.d.n.d.n.d.n.d.n.d.n.d.
7.89.5n.d.n.d.5.512n.d.n.d.n.d.n.d.

n.d.: not done; GM: gentamicin.
Discs of fosfomycin 31.2 µg/gentamicin 7.8 µg and fosfomycin 7.8 µg/gentamicin 2 µg mimicking cement 2 g fosfomycin/0.5 g gentamicin.
Discs of fosfomycin 15.6 µg/gentamicin 7.8 µg and fosfomycin 3.9 µg/gentamicin 2 µg mimicking cement 1 g fosfomycin/0.5 g gentamicin.
Discs of daptomycin 23.4 µg/gentamicin 7.8 µg and daptomycin 5.9 µg/gentamicin 2 µg mimicking cement 1.5 g daptomycin/0.5 g gentamicin.
Discs of fosfomycin 7.8 µg/gentamicin 7.8 µg and fosfomycin 2 µg/gentamicin 2 µg mimicking cement 0.5 g daptomycin/0.5 g gentamicin.