Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Table 3

Inhibition zones antibiotics (distance (mm) between test disk and bacterial growth).

Strain	GM (µg/disc)	Only GM	Fosfomycin (µg/disc)				Daptomycin (µg/disc)
			3.9	7.8	15.6	31.2	2	5.9	7.8	23.4
S. aureus ATCC 29213	0	0	0	4	6	7	5	6.5	7.5	8.5
	2	6	3.5	4	n.d.	n.d.	4.5	5	n.d.	n.d.
	7.8	8.5	n.d.	n.d.	6	7	n.d.	n.d.	5.5	6.5
S. aureus ATCC 43300	0	0	0	0	0	4.5	5.5	6.5	7.5	8.5
	2	0	0	0	n.d.	n.d.	1	2	n.d.	n.d.
	7.8	0	n.d.	n.d.	1	2	n.d.	n.d.	2.5	4.5
S. epidermidis DSM 8913	0	0	5	7.5	10	13.5	7	7.5	9	10
	2	0	13.5	15.5	n.d.	n.d.	4.5	7	n.d.	n.d.
	7.8	0	n.d.	n.d.	19.5	22	n.d.	n.d.	7	8
E. faecium DSM 13590	0	0	0	0	1	2.5	3	4	5	6.5
	2	0	0	8	n.d.	n.d.	0	4	n.d.	n.d.
	7.8	1	n.d.	n.d.	0	10	n.d.	n.d.	2	5
E. coli DSM 22311	0	0	6	8.5	9.5	12	n.d.	n.d.	n.d.	n.d.
	2	6	3	4	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
	7.8	9.5	n.d.	n.d.	5.5	12	n.d.	n.d.	n.d.	n.d.

n.d.: not done; GM: gentamicin.
Discs of fosfomycin 31.2 µg/gentamicin 7.8 µg and fosfomycin 7.8 µg/gentamicin 2 µg mimicking cement 2 g fosfomycin/0.5 g gentamicin.
Discs of fosfomycin 15.6 µg/gentamicin 7.8 µg and fosfomycin 3.9 µg/gentamicin 2 µg mimicking cement 1 g fosfomycin/0.5 g gentamicin.
Discs of daptomycin 23.4 µg/gentamicin 7.8 µg and daptomycin 5.9 µg/gentamicin 2 µg mimicking cement 1.5 g daptomycin/0.5 g gentamicin.
Discs of fosfomycin 7.8 µg/gentamicin 7.8 µg and fosfomycin 2 µg/gentamicin 2 µg mimicking cement 0.5 g daptomycin/0.5 g gentamicin.