Altered Erythropoiesis in Mouse Models of Type 3 Hemochromatosis
Hepcidin (Hamp) gene expression in Tfr2 targeted and in WT mouse liver at (a) 14 days (14 d) and (b) 10 weeks (10 w) of age. Erythroferrone (Erfe) gene expression in bone marrow (c) and spleen (d) of WT, KI, and KO mice at 14 days (14 d) and 10 weeks (10 w) of age. WT: wild type; KI: Tfr2 KI; KO: Tfr2 KO. The following symbols indicate statistically significant differences: and compared to age-matched WT mice; , , and compared to animals with the same genotype at 14 days of age.
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