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BioMed Research International
Volume 2017, Article ID 2418671, 9 pages
https://doi.org/10.1155/2017/2418671
Review Article

Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis

1Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China
2Chinese Material Medical School, Beijing University of Chinese Medicine, Beijing 100029, China
3The Research Institute of McGill University Health Center, Montreal, QC, Canada H4A 3J1
4Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 100029, China

Correspondence should be addressed to Dongwei Zhang; moc.liamg@6001iewgnod and Yu Li; moc.361@3791gnijiebuyil

Received 7 January 2017; Accepted 1 February 2017; Published 4 May 2017

Academic Editor: Ekaterina A. Ivanova

Copyright © 2017 Xuejiao Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Curcumin, a polyphenol derived from the turmeric, has received attention as a potential treatment for renal fibrosis primarily because it is a relatively safe and inexpensive compound that contributes to kidney health. Here, we review the literatures on the applications of curcumin in resolving renal fibrosis in animal models and summarize the mechanisms of curcumin and its analogs (C66 and (1E,4E)-1,5-bis(2-bromophenyl) penta-1,4-dien-3-one(B06)) in preventing inflammatory molecules release and reducing the deposition of extracellular matrix at the priming and activation stage of renal fibrosis in animal models by consulting PubMed and Cnki databases over the past 15 years. Curcumin exerts antifibrotic effect through reducing inflammation related factors (MCP-1, NF-κB, TNF-α, IL-1β, COX-2, and cav-1) and inducing the expression of anti-inflammation factors (HO-1, M6PRBP1, and NEDD4) as well as targeting TGF-β/Smads, MAPK/ERK, and PPAR-γ pathways in animal models. As a food derived compound, curcumin is becoming a promising drug candidate for improving renal health.