Recent Advances of Curcumin in the Prevention and Treatment of Renal Fibrosis

Figure 2

Nrf2 signaling pathway. Nrf2, as a transcription factor, resides within cytoplasm binding to the actin-associated Keap1 protein and is normally degraded. Upon oxidation stress, the association will be disrupted, resulting in the translocation of Nrf2 to nuclei and then increased expression of cytoprotective enzymes (HO-1, SOD, etc.).