Research Article

Prediction and Validation of Hub Genes Associated with Colorectal Cancer by Integrating PPI Network and Gene Expression Data

Figure 1

Flowcharts for deriving and validating hub genes in CRC. Expression profiles and corresponding clinical data for 645 CRC patients were obtained from The Cancer Genome Atlas (TCGA) data portal (July 2016). PPI network analysis based on differential expression genes between paired sets (normal and adjacent tumor tissue) was used to identify hub genes. Subsequently, patients with complete clinical information were included in the study to investigate the clinicopathology features and prognostic value of the identified hub genes.