Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children
Table 4
Effect of copy number in genes and intergenic regions on body mass index and waist circumference.
Factor
Type
β (95% CI
Gene
LEPR (intron 2)
BMI
Gain
−0.26 (−1.51; 0.98)
0.677
WC
−1.37 (−4.64; 1.91)
0.413
LEPR (intron 3)
BMI
Gain
−0.50 (−1.01; 0.02)
0.057
WC
−1.85 (−3.21; −0.49)
0.008
NEGR1
BMI
Gain
−0.64 (−1.10; −0.19)
0.006
WC
−2.03 (−3.24; −0.83)
0.001
ARHGEF4
BMI
Gain
0.63 (0.11; 1.15)
0.017
WC
1.45 (0.09; 2.81)
0.037
CPCXR1
BMI
Gain
0.66 (0.21; 1.11)
0.004
WC
2.10 (0.89; 3.30)
0.001
INS
BMI
Loss
0.77 (0.30; 1.25)
0.002
WC
2.20 (0.94; 3.45)
0.001
Intergenic regions
1p36.33b
BMI
Gain
0.06 (−0.46; 0.57)
0.829
WC
−0.13 (−1.47; 1.21)
0.852
12q15c
BMI
Gain
0.88 (0.36; 1.41)
0.001
WC
2.04 (0.65; 3.43)
0.004
15q21.1a
BMI
Gain
0.67 (0.20; 1.14)
0.005
WC
1.98 (0.75; 3.21)
0.002
22q11.21d
BMI
Gain
1.09 (0.59; 1.59)
<0.0001
WC
2.61 (1.29; 3.92)
<0.0001
regression models adjusted for age, gender, and family history of obesity. Children with 2 copies were chosen as the reference group. BMI: body mass index; WC: waist circumference.
