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BioMed Research International
Volume 2017, Article ID 2469826, 11 pages
Research Article

Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin in Pig against Korean Local Isolates of Actinobacillus pleuropneumoniae

Veterinary Drugs & Biologics Division, Animal and Plant Quarantine Agency (QIA), 177 Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea

Correspondence should be addressed to JeongWoo Kang; rk.aerok@hcajih and Kwang-jick Lee; rk.aerok@jwkeel

Received 19 December 2016; Revised 24 February 2017; Accepted 6 March 2017; Published 6 April 2017

Academic Editor: Ronald E. Baynes

Copyright © 2017 Md. Akil Hossain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The pharmacokinetics of marbofloxacin in pigs after intravenous (i.v.), intramuscular (i.m.), and peroral (p.o.) administration and pharmacokinetic/pharmacodynamic indices of this drug against Korean local isolates of Actinobacillus pleuropneumoniae were determined in this study. Marbofloxacin (2.50 mg/kg of body weight) was administered, and blood samples were collected with designated time intervals. Plasma-extracted marbofloxacin was injected into the LC-MS/MS system. The in vitro and ex vivo antibacterial activities of marbofloxacin were evaluated against 20 isolates of A. pleuropneumoniae. The mean peak plasma concentrations () after i.v., i.m., and p.o administration were , , and µg/mL at , , and  h, respectively. The area under the plasma concentration-time curves (AUC0–24) and elimination half-lives were , , and  h·μg/mL and , , and  h, for i.v., i.m., and p.o. administration, correspondingly. The AUC0–24/MICs of marbofloxacin after i.v., i.m., and p.o. administration were , , and  h, respectively. The /MIC values were , , and , and T>MICs were , , and  h, after i.v., i.m., and p.o. administration, respectively. Thus, marbofloxacin dosage of 2.50 mg/kg of body weight by i.v., i.m., and p.o. administration with 24 h dosing interval will provide effective treatment for the infection of pig by A. pleuropneumonia.