Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case

Table 1

PCN descriptors and their structural and biological relevance.

PCN descriptor	Structural and biological role
Node degree	Local stability [24]
Betweenness centrality (betw)	Signal transmission throughout the structure [26]
Closeness centrality (close)	Residues located in the active site of enzymes [26]
Participation Coefficient	Signal transmission through modules (domains) [27]
Intramodule Connectivity	Intramodule connectivity and communication [27]