Mutagenic and Cytotoxicity LQB 123 Profile: Safety and Tripanocidal Effect of a Phenyl-t-Butylnitrone Derivative

Table 1

LQB 123 effect upon Trypanosoma cruzi forms.

Parasite forms	IC50 (μM)	Time (h)	SI
Epimastigotes (Y strain)		24	>15
Metacyclic trypomastigotes (Dm28c)		24	>21
Bloodstream trypomastigotes (Y strain)		24	>16
Intracellular amastigotes (Y strain)		48	>21

The trypanocidal activity was expressed as the IC₅₀, corresponding to the concentration that leads to 50% parasite lysis.
CC₅₀ > 4000 μM (drug concentration which reduced 50% of peritoneal macrophage viability).
SI (selectivity index) = CC₅₀/IC₅₀.