Dab1 Contributes to Angiotensin II-Induced Apoptosis via p38 Signaling Pathway in Podocytes

Figure 1

Clinical and pathological changes. (a) Glomerular pathological changes with PAS staining (original magnification ×200, ×400); (A) control group in week 4; (B) Ang II-infused group in week 4. Scale bars, 50 μm. (C) Control group in week 4; (D) Ang II-infused group in week 4. Scale bars, 20 μm . (b) Apoptotic podocytes of rat kidneys were assessed by TUNEL staining (original magnification ×100, ×400); (A) control group in week 4; (B) Ang II-infused group in week 4; scale bars, 100 μm. (C) Control group in week 4; (D) Ang II-infused group in week 4. The black arrows indicate apoptotic podocytes. Scale bars, 20 μm . (c) Quantification of apoptotic podocytes. (d) Systolic blood pressure in weeks 1, 2, 3, and 4. (e) 24 h urinary albumin in weeks 1, 2, 3, and 4. versus control group.

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