Stellate Cell Activation and Imbalanced Expression of TGF-β1/TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice

Table 1

Liver function of the mice at each time point after intravenous injection of ConA.

Modeling time; (H)		ALT; (U/L)	AST; (U/L)	Albumin; ()  (g/L)	Globulin; ()  (g/L)	Ratio; ()
Control	8	38.8 ± 8.9	136 ± 24	26.3 ± 1.4	25.5 ± 1.2	1.02 ± 0.1
2	7	40.7 ± 6.5	170.6 ± 11.7	25.3 ± 1.6	24.6 ± 1.8	1.05 ± 0.1
8	5	208.8 ± 107.5	558.5 ± 180.1	26.5 ± 2.2	28.4 ± 0.7	0.9 ± 0.1
24	7	107.8 ± 41.4	259.7 ± 78.6	21.5 ± 8.3	30.2 ± 10.1	0.74 ± 0.2
48	8	68.1 ± 39.2	188 ± 59.4	21.9 ± 6.7	30.9 ± 9.7	0.68 ± 0.2

ALT and AST levels were significantly increased on 8 h after ConA injection, compared with the control group ( all < 0.01); after that time, a decreasing trend was observed,
24 h after ConA injection, ALT and AST levels were still higher than the level of control group ( all < 0.05).