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BioMed Research International
Volume 2017 (2017), Article ID 2543262, 6 pages
Research Article

Etiology of End-Stage Renal Disease and Arterial Stiffness among Hemodialysis Patients

1North Hospital Center, Zgharta, Northern Lebanon, Lebanon
2Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
3Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
4Lebanese American University School of Medicine, Byblos, Lebanon
5Lebanese University, School of Public Health, Beirut, Lebanon
6Diagnosis Center, Hotel-Dieu Hospital, Paris, France
7University Medical Center-Rizk Hospital, Beirut, Lebanon

Correspondence should be addressed to Sola Aoun Bahous

Received 21 November 2016; Revised 15 January 2017; Accepted 31 January 2017; Published 19 February 2017

Academic Editor: Veronica Swallow

Copyright © 2017 Balsam El Ghoul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Prior studies have demonstrated that conventional and emerging CV risk factors are associated with worsening arterial stiffness among end-stage renal disease (ESRD) patients on hemodialysis. The present cross-sectional study evaluates the association between the etiology of ESRD and arterial stiffness among a cohort of hemodialysis patients. Methods. Etiology of ESRD was identified from patients’ medical records and classified as either vascular renal disease, diabetic nephropathy, nondiabetic glomerulopathy, tubular interstitial nephropathy, hereditary nephropathy, or ESRD of unconfirmed etiology. Results. A total of 82 subjects were enrolled. cfPWV was independently associated with the composite of either diabetic nephropathy or vascular renal disease (), pulse pressure (), and a history of CV events (), but not history of hypertension or diabetes mellitus alone. The median cfPWVs in diabetic nephropathy and vascular renal disease were comparable and significantly higher than median cfPWVs in other etiologies of ESRD. Conclusion. The study suggests that the etiology of ESRD is independently associated with arterial stiffness among hemodialysis patients. Furthermore, arterial stiffness was higher among patients who developed renal sequelae of either diabetes mellitus or hypertension as compared with those who have a history of either diabetes mellitus or hypertension alone.