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BioMed Research International
Volume 2017, Article ID 2576921, 10 pages
Research Article

Modulation of Immune Function in Rats Using Oligosaccharides Extracted from Palm Kernel Cake

1Institute of Tropical Agriculture, Universiti Putra Malaysia (UPM), 43400 Serdang, Malaysia
2Agriculture Biotechnology Research Institute of Iran (ABRII), East and North-East Branch, P.O. Box 91735 844, Mashhad, Iran
3Faculty of Medicine, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia

Correspondence should be addressed to Mohammd Faseleh Jahromi; moc.oohay@imorhajfm and Juan Boo Liang; ym.ude.mpu@gnailbj

Received 3 April 2017; Revised 12 September 2017; Accepted 22 October 2017; Published 19 November 2017

Academic Editor: Leon Spicer

Copyright © 2017 Mohammd Faseleh Jahromi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate the prebiotic and immunomodulatory effects of PKC extract (OligoPKC) a total of 24 male rats were randomly assigned to three treatment groups receiving basal diet (control), basal diet containing 0.5% OligoPKC, or basal diet containing 1% OligoPKC for four weeks. We found that OligoPKC had no significant effect on the tested growth parameters. However, it increased the size of the total and beneficial bacterial populations while reducing pathogen populations. OligoPKC increased the concentration of immunoglobulins in the serum and cecal contents of rats. It also enhanced the antioxidant capacity of the liver while reducing lipid peroxidation in liver tissue. OligoPKC affected the expression of genes involved in immune system function in the intestine. Therefore, OligoPKC could be considered a potential mannan-based prebiotic for humans and animals due to its beneficial effects on the health and well-being of the model rats.