The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors
Microscopic evaluation of angiogenesis in serous ovarian tumors that developed in either the presence or absence of malignant ascites. The development of microvessels was analyzed according to immunohistochemical reactions against CD31 and CD34, that is, markers of endothelial cells. Panel (a) shows the representative results of CD31 and CD34 staining (the brown color indicates a positive reaction). Panels (b) and (c) show the results of the quantification of the brown-stained area reflecting the presence of CD31- (b) and CD34-positive cells (c). The results are expressed as a percentage (%), and the whole area of a specimen is considered to be 100%. versus ascites (−). The results derive from an analysis of tumors from 6 different patients per group and are expressed as mean ± SEM.
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