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BioMed Research International
Volume 2017, Article ID 2605628, 8 pages
Review Article

Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review

1Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
2Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy

Correspondence should be addressed to Gaia Peluso; moc.liamg@5osulep.aiag

Received 14 April 2017; Revised 18 September 2017; Accepted 3 October 2017; Published 29 October 2017

Academic Editor: Fotios Loupakis

Copyright © 2017 Gaia Peluso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic. Aim of the Review. Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC. Conclusion. Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice.