miR-200c Accelerates Hepatic Stellate Cell-Induced Liver Fibrosis via Targeting the FOG2/PI3K Pathway

Figure 2

miR-200c activates the PI3K/Akt pathway via suppressing expression of FOG2. (a) The level of phosphorylation at Akt residue S473 was significantly higher in LX2-200c cells than LX2-nc cells. (b) 25 μM LY-294002 (a PI3K inhibitor) significantly inhibited the expression of phospho-Akt in LX2-200c cells in a time-dependent manner. (c–e) 25 μM LY-294002 significantly inhibited the proliferation and migration of LX2-200c cells. (f) There was the significantly lower levels of FOG2 expression in LX2-200c cells, while no significant change was observed in PI3K expression. means , means , and means .

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