Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila

Figure 6

Brain tumour growth induced by aPKC activation is MYC-dependent. ((a)-(b)) Representative brains from Optix- larvae grown at 25°C. (a) MYC (red) and Lgl (white) staining. Regions II and OL in the GFP⁺ inset indicate type II and OL NBs, respectively. (b) The arrow indicates the NE-medulla region and the arrowhead points to the type II NBs in the DM region. (c) The same regions as in (b) are indicated in an Optix- brain. (d) Representative brains from Optix- larvae grown at 25°C stained for MYC (red) and Lgl (white). The GFP⁺ inset shows the huge expansion of the type II NBs (region II). (e) Optix- representative adult brains from 1–4-day-old animals showing MYC upregulation associated with Yki accumulation (arrows). Scale bars are 50 μm.

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