Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Rheumatoid Arthritis

Table 2

Monocyte subpopulation frequency and osteoclastogenic marker expression.

	Baseline	Follow-up	value
Classic (%)	88 [82–89]	78 [70–83]
Classic CD51/CD61 MFI	130 [119–148]	125 [111–137]	0.4258
Classic RANK MFI	133 [116–160]	122 [100–135]	0.1849
Intermediate	4.4 [2.4–5.6]	4.0 [2.1–7.1]	0.6013
Intermediate CD51/CD61 MFI	222 [139–400]	193 [146–240]	0.8203
Intermediate RANK MFI	197 [117–361]	188 [120–272]	0.9102
Nonclassic	5.7 [4.1–11]	14 [11.5–18.1]
Nonclassic CD51/CD61 MFI	192 [80–290]	142 [127–167]	0.5703
Nonclassic RANK MFI	139 [122–157]	138 [126–146]	1.0000

Flow cytometry results are shown as median and interquartile range; on the monocyte subpopulation from peripheral blood mononuclear cells. RANK: receptor activator of nuclear factor-κB; MFI: median fluorescence intensity (arbitrary units); , . ^†Remained significant after correction for multiple comparisons.