Scientific Evidence for Different Options for GDM Screening and Management: Controversies and Review of the Literature

Table 2

RCTs of treatment versus no treatment of GDM, focusing on women positive for the One-Step but negative for the Two-Step test.

Study	Screening test	Diagnostic test	Values for diagnosis	Intervention group	Control group	Primary outcome
O’Sullivan et al., 1966 (USA) [13]	50 g GCT: positive if ≥130 mg/dl	100 g, 3 h (110-170-120-110)	2 or more values	Insulin	Routine care	LGA
Coustan and Lewis, 1978 (USA) [14]	50 g GCT: positive if ≥130 mg/dl	100 g, 3 h (95-180-160-135)	2 or more values	Insulin	Routine care	Macrosomia
Thompson et al., 1990 (USA) [15]	50 g GCT: positive if  mg/dL or 1 h > 140 mg/dL	100 g, 3 h (105-190-165-145)	2 or more values	Insulin	Routine care	Maternal and neonatal morbidity
Crowther et al., 2005 (Australia) [16]	50 g GCT: positive if ≥140 mg/dl	75 g OGTT (; 2 h 7.8–10 mmol/L)	Both values	Insulin	Routine care	Perinatal complications
Landon et al., 2009 (USA) [17]	50 g GCT: positive if ≥135 mg/dl	100 g, 3 h (95-180-155-140)	2 or more values but  mg/dL	Insulin	Routine care	Perinatal outcome
Casey et al., 2015 (USA) [18]	50 g GCT: positive if ≥140 mg/dL	100 g, 3 h (105-190-165-145)	2 values	Glyburide	Placebo	Birth weight