Review Article

Scientific Evidence for Different Options for GDM Screening and Management: Controversies and Review of the Literature

Table 4

Prospective non-RCTs or retrospective studies comparing incidence of GDM and/or outcomes between the One-Step and Two-Step methods.

Author (origin)Study designTwo-Step groupOne-Step groupGDM ratePrimary outcome

Duran et al., 2014 (Spain) [22]Retroprospective cohortACOG: 50 g 1 h GCT; if >140 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT10.6% versus 35.5%Pregnancy outcomes
Fuller and Borgida, 2014 (USA) [23]Retroprospective cohortACOG: 50 g 1 h GCT; if >135 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT7.0% versus 11.7%Maternal and delivery outcomes
Liu et al., 2014 (China) [24]Retrospective cohortACOG: 50 g 1 h GCT; if >140 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT7.0% versus 20.4%Maternal and perinatal outcomes
Oriot et al., 2014 (Belgium) [25]Retrospective cohortACOG: 50 g 1 h GCT; if >140 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT8.0% versus 23.0%CS, macrosomia
Wei et al., 2014 (China) [26]Retrospective cohortACOG: 50 g 1 h GCT; if >135 mg/dL followed by 75 g 3 h GTT (NDDG)IADPSG: 75 g 2 h GTT18.3% versus 21.0%CS, macrosomia
Hung and Hsieh, 2015 (Taiwan) [27]Retrospective cohortACOG: 50 g 1 h GCT; if >140 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT4.6% versus 12.4%Macrosomia, LGA
Kong et al., 2015 (Canada) [28]Retrospective cohortACOG: 50 g 1 h GCT; if >140 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT7.9% versus 9.4%Maternal and fetal outcomes
Assaf-Balut et al., 2016 (Spain) [29]Retrospective cohortADA: 50 g 1 h GCT; if >140 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTTNot statedPostpartum disorders
Klara Feldman et al., 2016 (USA) [30]Retroprospective cohortACOG: 50 g 1 h GCT; if >130 mg/dL followed by 100 g 3 h GTT (C&C)IADPSG: 75 g 2 h GTT if HbA1c < 5.7%17.0% versus 27.0%Pregnancy outcomes