Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Table 4

Linear regression analyses of the genetic associations among SNP and lung function, COPD severity, and smoking amount in the subjects with COPD.

	Subjects with COPD ()
	FEV1		FEV1 pre-BD		The FEV1/FVC%		GOLD		Pack-years		Smoking status
	β (SE)		β (SE)		β (SE)		β (SE)		β (SE)		β (SE)
rs12509311	0.052 (0.033)	0.122	0.041 (0.025)	0.105	2.683 (0.757)	4.1e^−4	−0.020 (0.044)	0.644	1.317 (1.257)	0.153	−0.030 (0.026)	0.251
rs13118928	0.057 (0.033)	0.089	0.040 (0.025)	0.108	2.743 (0.754)	2.8e^−4	−0.027 (0.044)	0.538	1.392 (1.257)	0.145	−0.036 (0.026)	0.172
rs1828591	0.052 (0.033)	0.122	0.041 (0.025)	0.105	2.683 (0.757)	4.1e^−4	−0.020 (0.044)	0.644	1.317 (1.257)	0.153	−0.030 (0.026)	0.251

with adjusting gender, age, and pack-years of smoking in linear regression. Statistical powers are 0.85, 0.86, and 0.85 for rs12509311, rs13118928, and rs1828591 in the FEV1/FVC%, respectively. The data presented are β (SE) with two-sided value. FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; in bold is .