Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease

Table 5

Effect of risk allele and genotypes of 3 SNPs in the HHIP gene on the FEV1/FVC% in the subjects with COPD.

	Subjects with COPD ()
	Crude		Adjusted
	β (SE)		β (SE)
Risk allele	1.328 (0.309)	1.9e^−5	1.077 (0.292)	2.3e^−4
Risk	2.058 (0.490)	2.7e^−5	1.651 (0.462)	3.5e^−4

in a linear regression model that included gender, age, and pack-years of smoking; risk allele means number of the three SNPs in combination. combinations in HHIP: rs12509311T variant genotypes (CT or TT), rs13118928G variant genotypes (AG or GG), or rs1828591G variant genotypes (AG or GG) are defined as risk genotypes. Risk genotype means number of variant genotypes in combination. The data presented are β (SE) with two-sided value. In bold is .