Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017 (2017), Article ID 2831056, 9 pages
https://doi.org/10.1155/2017/2831056
Research Article

Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200a/Beta-Catenin Axis

Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Correspondence should be addressed to Shan-yu Qin

Received 16 November 2016; Revised 7 February 2017; Accepted 14 February 2017; Published 2 March 2017

Academic Editor: Anton M. Jetten

Copyright © 2017 Bangli Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, R. Siegel, J. Xu, and E. Ward, “Cancer statistics, 2010,” CA Cancer Journal for Clinicians, vol. 60, no. 5, pp. 277–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Humphries and C. Yang, “The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy,” Oncotarget, vol. 6, no. 9, pp. 6472–6498, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Nishijima, M. Seike, C. Soeno et al., “miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells,” International Journal of Oncology, vol. 48, no. 3, pp. 937–944, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Pu, Y. Zhang, and J. Zhou, “Effect of Huai Qi Huang on epithelial-mesenchymal transition of renal tubular epithelial cells through miR-200a,” Evidence-based Complementary and Alternative Medicine, vol. 2016, Article ID 8612190, 9 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Soubani, A. S. Ali, F. Logna, S. Ali, P. A. Philip, and F. H. Sarkar, “Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer,” Carcinogenesis, vol. 33, no. 8, pp. 1563–1571, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Feng, J. Wang, M. Chen et al., “MiR-200a suppresses cell growth and migration by targeting MACC1 and predicts prognosis in hepatocellular carcinoma,” Oncology Reports, vol. 33, no. 2, pp. 713–720, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Wu, G. Wu, Z. Wu, X. Yao, and G. Li, “MiR-200a suppresses the proliferation and metastasis in pancreatic ductal adenocarcinoma through downregulation of DEK gene,” Translational Oncology, vol. 9, no. 1, pp. 25–31, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Vegran, L. Apetoh, and F. Ghiringhelli, “Th9 cells: a novel CD4 T-cell Subset in the immune war against cancer,” Cancer Research, vol. 75, no. 3, pp. 475–479, 2015. View at Publisher · View at Google Scholar
  9. P. G. Fallon, P. Smith, E. J. Richardson et al., “Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections,” Infection and Immunity, vol. 68, no. 10, pp. 6005–6011, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Horka, V. Staudt, M. Klein et al., “The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma,” Journal of Immunology, vol. 188, no. 6, pp. 2669–2676, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Nizsalóczki, I. Csomós, P. Nagy et al., “Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells,” ChemPhysChem, vol. 15, no. 18, pp. 3969–3978, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Knoops and J.-C. Renauld, “IL-9 and its receptor: from signal transduction to tumorigenesis,” Growth Factors, vol. 22, no. 4, pp. 207–215, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Chen, K. Lu, P. Li, X. Lv, and X. Wang, “Overexpression of IL-9 induced by STAT6 activation promotes the pathogenesis of chronic lymphocytic leukemia,” International Journal of Clinical and Experimental Pathology, vol. 7, no. 5, pp. 2319–2323, 2014. View at Google Scholar · View at Scopus
  14. J. Zhang, W.-D. Wang, Q.-R. Geng et al., “Serum levels of interleukin-9 correlate with negative prognostic factors in extranodal NK/T-cell lymphoma,” PLoS ONE, vol. 9, no. 4, Article ID e94637, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Chen, X. Liu, X. Chen et al., “Real-time monitoring of mirna function in pancreatic cell lines using recombinant aav-based mirna asensors,” PLOS ONE, vol. 8, no. 6, Article ID e66315, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Wu, Z. Li, P. Yang, L. Zhang, Y. Fan, and Z. Li, “PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells,” Cellular Signalling, vol. 26, no. 11, pp. 2397–2405, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. Zhen, J. Liu, L. Gao et al., “MicroRNA-200a Targets EGFR and c-Met to Inhibit Migration, Invasion, and Gefitinib Resistance in Non-Small Cell Lung Cancer,” Cytogenetic and Genome Research, vol. 146, pp. 1–8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Liu, B. Ruan, N. You et al., “Downregulation of miR-200a induces EMT phenotypes and CSC-like signatures through targeting the β-catenin pathway in hepatic oval cells,” PLoS ONE, vol. 8, no. 11, Article ID e79409, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Purwar, C. Schlapbach, S. Xiao et al., “Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells,” Nature Medicine, vol. 18, no. 8, pp. 1248–1253, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. S. E. Smith, D. B. Hoelzinger, A. L. Dominguez, J. Van Snick, and J. Lustgarten, “Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses,” Cancer Immunology, Immunotherapy, vol. 60, no. 12, pp. 1775–1787, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Huang, Y. Cao, S. Zhang, and F. Gao, “Association between low expression levels of interleukin-9 and colon cancer progression,” Experimental and Therapeutic Medicine, vol. 10, no. 3, pp. 942–946, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. D. B. Hoelzinger, A. L. Dominguez, P. A. Cohen, and S. J. Gendler, “Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid t-cell sensitization and rejection of progressive tumor challenges,” Cancer Research, vol. 74, no. 23, pp. 6845–6855, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. W. Elyaman, E. M. Bradshaw, C. Uyttenhove et al., “IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 31, pp. 12885–12890, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. C. Nowak, C. T. Weaver, H. Turner et al., “IL-9 as a mediator of Th17-driven inflammatory disease,” Journal of Experimental Medicine, vol. 206, no. 8, pp. 1653–1660, 2009. View at Publisher · View at Google Scholar · View at Scopus