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BioMed Research International
Volume 2017, Article ID 2837027, 8 pages
Research Article

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

1Department of Obstetrics and Gynecology, University Hospital of the RWTH Aachen, Aachen, Germany
2Department of Medical Biometrics and Statistics, University of Lübeck, Lübeck, Germany
3Department of Neonatology, University Children’s Hospital of the RWTH Aachen, Aachen, Germany
4Department of Pediatrics, University Hospital UKSH Lübeck, Lübeck, Germany
5Department of Obstetrics and Gynecology, University Hospital UKSH Kiel, Kiel, Germany

Correspondence should be addressed to Ulrich Pecks; ed.nehcaaku@skcepu

Received 27 January 2017; Revised 8 March 2017; Accepted 23 March 2017; Published 5 April 2017

Academic Editor: Erich Cosmi

Copyright © 2017 Stephen Norda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (≥22+0 and <32+0 weeks of gestation and birth weight below 1500 g) from the GNN study cohort was analyzed. Neonates were categorized into subgroups of <3rd, 3rd–10th, and >10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan® SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.