BioMed Research International / 2017 / Article / Tab 4

Research Article

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Table 4

Analysis of interactive effect of ApoE genotype and subgroups with placental syndrome (PIH/HELLP, IUGR/pathologic Doppler) on birth weight percentile groups.

FactorEstimateSE valueNominal PAdjusted P

e2/e30.48910.53590.91270.361
e3/e30.56670.52561.07810.281
e3/e40.43050.52970.81280.421
e4/e40.72210.60481.19390.231
e2/e40.56350.60800.92680.351
PIH/HELLP0.1224<0.0001<0.0001
IUGR0.0971<0.0001<0.0001

Results of analyzing the effect of individual ApoE genotypes with underlying maternal pathology, respectively, on birth weight percentile. Data were compared to reference group e2/e2 for genotype analysis and to no placental syndrome, respectively.
Patients with both, “PIH/HELLP” and “IUGR/pathological Doppler ultrasound,” were grouped into the “IUGR/pathological Doppler ultrasound” subgroup. All values are rounded on four decimals. The type I error level was set to 0.05. Adjusted values are adjusted according to the Bonferroni-Holm procedure.