Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Table 4

Analysis of interactive effect of ApoE genotype and subgroups with placental syndrome (PIH/HELLP, IUGR/pathologic Doppler) on birth weight percentile groups.

Factor	Estimate	SE	value	Nominal P	Adjusted P
e2/e3	0.4891	0.5359	0.9127	0.36	1
e3/e3	0.5667	0.5256	1.0781	0.28	1
e3/e4	0.4305	0.5297	0.8128	0.42	1
e4/e4	0.7221	0.6048	1.1939	0.23	1
e2/e4	0.5635	0.6080	0.9268	0.35	1
PIH/HELLP		0.1224		<0.0001	<0.0001
IUGR		0.0971		<0.0001	<0.0001

Results of analyzing the effect of individual ApoE genotypes with underlying maternal pathology, respectively, on birth weight percentile. Data were compared to reference group e2/e2 for genotype analysis and to no placental syndrome, respectively.
Patients with both, “PIH/HELLP” and “IUGR/pathological Doppler ultrasound,” were grouped into the “IUGR/pathological Doppler ultrasound” subgroup. All values are rounded on four decimals. The type I error level was set to 0.05. Adjusted values are adjusted according to the Bonferroni-Holm procedure.