Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017 (2017), Article ID 2869405, 7 pages
https://doi.org/10.1155/2017/2869405
Research Article

Relaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro

1Department of Nephrology, Hangzhou First People’s Hospital, Nanjing Medical University, Hangzhou, Zhejiang, China
2Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu, China

Correspondence should be addressed to Ming Wang; ten.haey@tcodgnimgnaw

Received 18 January 2017; Revised 22 March 2017; Accepted 26 March 2017; Published 30 April 2017

Academic Editor: Goutam Ghosh Choudhury

Copyright © 2017 Xiang-Cheng Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Mehran and E. Nikolsky, “Contrast-induced nephropathy: definition, epidemiology, and patients at risk,” Kidney International Supplements, vol. 100, pp. S11–S15, 2006. View at Publisher · View at Google Scholar
  2. A. Khwaja, “KDIGO clinical practice guidelines for acute kidney injury,” Nephron. Clinical Practice, vol. 120, no. 4, pp. c179–c184, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Nash, A. Hafeez, and S. Hou, “Hospital-acquired renal insufficiency,” American Journal of Kidney Diseases, vol. 39, no. 5, pp. 930–936, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. M. T. James, S. M. Samuel, M. A. Manning et al., “Contrast-induced acute kidney injury and risk of adverse clinical outcomes after coronary angiography: a systematic review and meta-analysis,” Circulation: Cardiovascular Interventions, vol. 6, no. 1, pp. 37–43, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Abaci, O. Harmankaya, B. Kocas et al., “Long-term follow-up of patients at high risk for nephropathy after contrast exposure,” Angiology, vol. 66, no. 6, pp. 514–518, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Azzalini, V. Spagnoli, and H. Q. Ly, “Contrast-induced nephropathy: from pathophysiology to preventive strategies,” Canadian Journal of Cardiology, vol. 32, no. 2, pp. 247–255, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Romano, C. Briguori, C. Quintavalle et al., “Contrast agents and renal cell apoptosis,” European Heart Journal, vol. 29, no. 20, pp. 2569–2576, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Linkermann, G. Chen, G. Dong, U. Kunzendorf, S. Krautwald, and Z. Dong, “Regulated cell death in AKI,” Journal of the American Society of Nephrology, vol. 25, no. 12, pp. 2689–2701, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. H.-C. Lee, J.-G. Chang, H.-W. Yen, I.-H. Liu, W.-T. Lai, and S.-H. Sheu, “Ionic contrast media induced more apoptosis in diabetic kidney than nonionic contrast media,” Journal of Nephrology, vol. 24, no. 3, pp. 376–380, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Peer, Z. Averbukh, S. Berman, D. Modai, M. Averbukh, and J. Weissgarten, “Contrast media augmented apoptosis of cultured renal mesangial, tubular, epithelial, endothelial, and hepatic cells,” Investigative Radiology, vol. 38, no. 3, pp. 177–182, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Yano, Y. Itoh, T. Sendo, T. Kubota, and R. Oishi, “Cyclic AMP reverses radiocontrast media-induced apoptosis in LLC-PK1 cells by activating a kinase/PI3 kinase,” Kidney International, vol. 64, no. 6, pp. 2052–2063, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. E. B. Bass and R. M. Subramaniam, “Prevention strategies for contrast-induced nephropathy,” Annals of Internal Medicine, vol. 165, no. 8, p. 601, 2016. View at Publisher · View at Google Scholar
  13. P. Pattharanitima and A. Tasanarong, “Pharmacological strategies to prevent contrast-induced acute kidney injury,” BioMed Research International, vol. 2014, Article ID 236930, 21 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Yoshida, H. Kumagai, T. Kohsaka, and N. Ikegaya, “Protective effects of relaxin against cisplatin-induced nephrotoxicity in rats,” Nephron—Experimental Nephrology, vol. 128, no. 1-2, pp. 9–20, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. X.-L. Moore, S.-L. Tan, C.-Y. Lo et al., “Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes,” Endocrinology, vol. 148, no. 4, pp. 1582–1589, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Hardiek, R. E. Katholi, V. Ramkumar, and C. Deitrick, “Proximal tubule cell response to radiographic contrast media,” American Journal of Physiology—Renal Physiology, vol. 280, no. 1, pp. F61–F70, 2001. View at Google Scholar · View at Scopus
  17. C. Quintavalle, M. Brenca, F. De Micco et al., “In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis,” Cell Death and Disease, vol. 2, no. 5, article e155, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. G. J. Ko, S. Y. Bae, Y.-A. Hong, H. J. Pyo, and Y. J. Kwon, “Radiocontrast-induced nephropathy is attenuated by autophagy through regulation of apoptosis and inflammation,” Human and Experimental Toxicology, vol. 35, no. 7, pp. 724–736, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Andreucci, T. Faga, D. Russo et al., “Differential activation of signaling pathways by low-osmolar and Iso-osmolar radiocontrast agents in human renal tubular cells,” Journal of Cellular Biochemistry, vol. 115, no. 2, pp. 281–289, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Michael, T. Faga, A. Pisani et al., “Molecular mechanisms of renal cellular nephrotoxicity due to radiocontrast media,” BioMed Research International, vol. 2014, Article ID 249810, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Andreucci, G. Fuiano, P. Presta et al., “Radiocontrast media cause dephosphorylation of Akt and downstream signaling targets in human renal proximal tubular cells,” Biochemical Pharmacology, vol. 72, no. 10, pp. 1334–1342, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Johnson and L. A. Di Pietro, “Apoptosis and angiogenesis: an evolving mechanism for fibrosis,” FASEB Journal, vol. 27, no. 10, pp. 3893–3901, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. J. K. Brunelle and A. Letai, “Control of mitochondrial apoptosis by the Bcl-2 family,” Journal of Cell Science, vol. 122, no. 4, pp. 437–441, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. T. van der Westhuizen, M. L. Halls, C. S. Samuel et al., “Relaxin family peptide receptors—from orphans to therapeutic targets,” Drug Discovery Today, vol. 13, no. 15-16, pp. 640–651, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. V. Cernaro, A. Lacquaniti, R. Lupica et al., “Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein,” Medicinal Research Reviews, vol. 34, no. 1, pp. 77–105, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Yoshida, H. Kumagai, T. Kohsaka, and N. Ikegaya, “Relaxin protects against renal ischemia-reperfusion injury,” American Journal of Physiology—Renal Physiology, vol. 305, no. 8, pp. F1169–F1176, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. B. S. M. Chow, M. Kocan, S. Bosnyak et al., “Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis,” Kidney International, vol. 86, no. 1, pp. 75–85, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. P. A. McCullough and J. L. Jefferies, “Novel markers and therapies for patients with acute heart failure and renal dysfunction,” American Journal of Medicine, vol. 128, no. 3, pp. 312.e1–312.e22, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. M.-J. Xu, D. Feng, H. Wang, Y. Guan, X. Yan, and B. Gao, “IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium,” Journal of the American Society of Nephrology, vol. 25, no. 5, pp. 967–977, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. B. D. Manning and L. C. Cantley, “AKT/PKB signaling: navigating downstream,” Cell, vol. 129, no. 7, pp. 1261–1274, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Koyasu, “The role of PI3K in immune cells,” Nature Immunology, vol. 4, no. 4, pp. 313–319, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. S. R. Datta, H. Dudek, T. Xu et al., “Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery,” Cell, vol. 91, no. 2, pp. 231–241, 1997. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Zhou, H. Zhen, Y. Mei et al., “PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis,” Cellular and Molecular Immunology, vol. 6, no. 3, pp. 175–180, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Sunayama, F. Tsuruta, N. Masuyama, and Y. Gotoh, “JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3,” Journal of Cell Biology, vol. 170, no. 2, pp. 295–304, 2005. View at Publisher · View at Google Scholar · View at Scopus