Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population
Table 3
Allele and genotype frequencies of the five SNPs in DM/PM patients and healthy controls.
Gene
SNP
Groups
Allele (%)
OR (95% CI)
Genotype (%)
TNFSF4
rs2205960
T
G
TT
TG
GG
DM
344 (26.30)
964 (73.70)
1.00 (0.86–1.16)
NS
43 (6.57)
258 (39.45)
353 (53.98)
0.30
NS
PM
197 (27.13)
529 (72.87)
1.04 (0.87–1.26)
NS
21 (5.79)
155 (42.70)
187 (51.52)
0.59
NS
DM/PM
541 (26.60)
1493 (73.40)
1.01 (0.89–1.16)
NS
64 (6.29)
413 (40.61)
540 (53.10)
0.05
NS
Controls
674 (26.33)
1886 (73.67)
78 (6.09)
518 (40.47)
684 (53.44)
TNFSF4
rs844644
C
A
CC
CA
AA
DM
601 (45.95)
707 (54.05)
1.10 (0.96–1.26)
0.850
129 (19.72)
343 (52.45)
182 (27.83)
3.17
NS
PM
325 (44.77)
401 (55.23)
1.05 (0.89–1.24)
NS
67 (18.46)
191 (52.62)
105 (28.93)
1.40
NS
DM/PM
926 (45.53)
1108 (54.47)
1.08 (0.96–1.21)
0.995
196 (19.27)
534 (52.51)
287 (28.22)
3.53
0.855
Controls
1116 (43.63)
1442 (56.37)
243 (19.00)
630 (49.26)
406 (31.74)
TNFSF4
rs844648
A
G
AA
AG
GG
DM
607 (46.41)
701 (53.59)
1.08 (0.94–1.23)
NS
129 (19.72)
349 (53.36)
176 (26.91)
5.53
0.315
PM
332 (45.73)
394 (54.27)
1.05 (0.89–1.24)
NS
68 (18.73)
196 (53.99)
99 (27.27)
4.07
0.655
DM/PM
939 (46.17)
1095 (53.83)
1.07 (0.95–1.20)
NS
197 (19.37)
545 (53.59)
275 (27.04)
7.50
0.115
Controls
1141 (44.57)
1419 (55.43)
263 (20.55)
615 (48.05)
402 (31.41)
ANKRD55
rs6859219
A
C
AA
AC
CC
DM
5 (0.38)
1303 (99.62)
0.75 (0.27–2.11)
NS
0 (0.00)
5 (0.76)
649 (99.24)
NA
NA
PM
5 (0.69)
721 (99.31)
1.36 (0.48–3.82)
NS
0 (0.00)
5 (1.38)
358 (98.62)
NA
NA
DM/PM
10 (0.49)
2024 (99.51)
0.97 (0.42–2.21)
NS
0 (0.00)
10 (0.98)
1007 (99.02)
NA
NA
Controls
13 (0.51)
2547 (99.49)
0 (0.00)
13 (1.02)
1267 (98.98)
ANKRD55
rs7731626
A
G
AA
AG
GG
DM
99 (7.57)
1209 (92.43)
0.76 (0.59–0.96)
0.120
5 (0.76)
89 (13.61)
560 (85.63)
4.93
0.425
PM
58 (7.99)
668 (92.01)
0.80 (0.60–1.08)
0.735
1 (0.28)
56 (15.43)
306 (84.30)
NA
NA
DM/PM
157 (7.72)
1877 (92.28)
0.77 (0.63–0.95)
0.075
6 (0.59)
145 (14.26)
866 (85.15)
6.14
0.23
Controls
250 (9.77)
2310 (90.23)
16 (1.25)
218 (17.03)
1046 (81.72)
SNPs = single nucleotide polymorphisms; DM = dermatomyositis; PM = polymyositis; OR = odds ratio; CI = confidence interval; Pc = value corrected by Bonferroni method; = Chi-square test; NS = not significant; NA = not available.
