HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression

Figure 2

HPV16 E6 promotes the proliferation of breast cancer by upregulating COX-2 expression. (a) The expression of HPV16 E6 and COX-2 expression in MCF-7/HPV16 E6 and MCF-7/Vector cells. (b) The construction of cells with HPV16 E6 expression and COX-2 suppression which induced by siCOX-2 and Celecoxib. (c)–(e) The proliferative ability of the indicated cells detected by MTT assays, colony formation assays, and soft agar assays. Only cell colonies containing more than 50 cells were counted. Error bars represent mean ± SD from 3 independent experiments. .

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