HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression

<div><i>HPV16 E6 expression positively correlates with COX-2 expression in breast cancer. </i>(a) The expression of COX-2 DNA in HPV16 E6 positive and negative invasive ductal breast cancer samples by qPCR analysis (<svg height="11.97pt" id="M128" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.9202 35.4417 11.97" width="35.4417pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z" id="g113-51"></path></g><g transform="matrix(.0091,0,0,-0.0091,6.24,-5.741)"><path d="M469 201V252H50V201H469Z" id="g190-178"></path></g><g transform="matrix(.0091,0,0,-0.0091,10.99,-5.741)"><path d="M610 0V27L347 666L316 657L46 26V0H610ZM504 54H116L310 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403 482 380 482 289Z" id="g113-113"></path></g><g transform="matrix(.013,0,0,-0.013,23.03,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path></g><g transform="matrix(.013,0,0,-0.013,34.293,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,40.533,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path></g><g transform="matrix(.013,0,0,-0.013,43.497,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,49.737,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg>.</span> (b) The representative images of HPV16 E6 and COX-2 expression in invasive ductal breast carcinoma tissues by IHC.</div>

BioMed Research International

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Figure 3

Figure 3: HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression 