Research Article

MicroRNA-16-5p Inhibits Osteoclastogenesis in Giant Cell Tumor of Bone

Figure 1

miR-16-5p is downregulated in GCTB. (a) Plain films of subjects in the GCT group showing different degrees of bone destruction (arrows indicated). (b) H&E staining of GCT slices in patients with different degrees of bone destruction. Panel (b) shows the multinucleated osteoclast-like giant cells (indicated by arrows) in the pathological images of patients for Campanacci Grades I, II, and III, respectively. Scale bars represent 10 μm. (c) The average numbers of osteoclast-like multinucleated cells. (d) The average area of the osteoclast-like multinucleated cells. (e) Quantification of miR-16-5p mRNA expression in patients with GCT with different degrees of bone destruction. (f–h) TRAP staining of GCT slices in patients with different degrees of bone destruction. Scare bar represents 20 μm.   and  . P values were analyzed using the one-way ANOVA test.