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BioMed Research International
Volume 2017, Article ID 3489603, 7 pages
Research Article

The Association between Age-Related Macular Degeneration and the Risk of Mortality

1Department of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Xueyuanxi Road, No. 109, Wenzhou, Zhejiang 325000, China
2Department of Neurology, Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, China

Correspondence should be addressed to Xueqiang Guan; moc.361@qxgszw

Received 6 March 2017; Revised 23 April 2017; Accepted 27 April 2017; Published 18 May 2017

Academic Editor: Alfredo García-Layana

Copyright © 2017 Peipei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Studies have investigated the association between age-related macular degeneration (AMD) and subsequent risks of mortality, but results have been equivocal. We conducted a comprehensive analysis of prospective cohort studies to assess the association of AMD and the risk of mortality in the general population. We searched PubMed and EMBASE for trials published from 1980 to 2016. We included 11 cohort studies that reported relative risks with 95% confidence intervals for the association of AMD and mortality, involving 57,069 participants. In a random-effects model, the adjusted RR (95% confidence interval) associated with AMD was 1.09 (1.02–1.17) for all-cause mortality. Findings from this research provide support that persons with AMD had a higher subsequent risk of mortality than persons without AMD.