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BioMed Research International
Volume 2017 (2017), Article ID 3512784, 12 pages
Research Article

Effect of Gonadotropin Types and Indications on Homologous Intrauterine Insemination Success: A Study from 1251 Cycles and a Review of the Literature

1ART and Reproductive Biology, University Hospital and School of Medicine, Picardie University Jules Verne, CHU Sud, 80054 Amiens, France
2PERITOX-INERIS Laboratory, CURS, Picardie University Jules Verne, CHU Sud, 80054 Amiens, France
3Laboratoire Lavergne, ACCOLAB, 75016 Paris, France
4Unilabs France et ForteBio, 1 rue Mozart, 92200 Clichy La Garenne, France

Correspondence should be addressed to Moncef Benkhalifa

Received 2 August 2017; Revised 14 November 2017; Accepted 21 November 2017; Published 13 December 2017

Academic Editor: Marco Scioscia

Copyright © 2017 Rosalie Cabry-Goubet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the IUI success factors relative to controlled ovarian stimulation (COS) and infertility type, this retrospective cohort study included 1251 couples undergoing homologous IUI. Results. We achieved 13% clinical pregnancies and 11% live births. COS and infertility type do not have significant effect on IUI clinical outcomes with unstable intervention of various couples’ parameters, including the female age, the IUI attempt rank, and the sperm quality. Conclusion. Further, the COS used seemed a weak predictor for IUI success; therefore, the indications need more discussion, especially in unexplained infertility cases involving various factors. Indeed, the fourth IUI attempt, the female age over 40 years, and the total motile sperm count <5 × 106 were critical in decreasing the positive clinical outcomes of IUI. Those parameter cut-offs necessitate a larger analysis to give infertile couples more chances through IUI before carrying out other ART techniques.