In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process

Figure 3

Influence of “prophylactic” intraperitoneal application (once daily from day 0 until day 21 after the first dose of collagen) of phage lysate, sonicate of their hosts, and broth (0.5 ml/mouse) given on the course of CIA. (a) 119x phage lysate (6 × 10⁵ pfu/mouse) and its host P. aeruginosa 119x strain sonicate (number of mice in groups: = 12–15). (b) Phi200 phage lysate (1.4 × 10⁷ pfu/mouse) and its host S. aureus 6409 strain sonicate (number of mice in groups: = 13–15). (c) Broth used in the process of phage propagation (number of mice in groups: = 13-14). in comparison to the control group (Mann–Whitney U test). For clarity reasons only upper or lower error bars representing SE are shown.

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