BioMed Research International
Volume 2017 (2017), Article ID 3681707, 11 pages
https://doi.org/10.1155/2017/3681707
PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou 510060, China
2Biobank of Eye, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, Guangzhou 510060, China
Correspondence should be addressed to Huangxuan Shen; nc.ude.usys.liam@xhnehs
Received 26 October 2016; Revised 22 January 2017; Accepted 26 January 2017; Published 22 February 2017
Academic Editor: Maria Dolores Pinazo-Duran
Copyright © 2017 Jia He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- R. D. Jager, W. F. Mieler, and J. W. Miller, “Age-related macular degeneration,” New England Journal of Medicine, vol. 358, no. 24, pp. 2544–2617, 2008. View at Publisher · View at Google Scholar · View at Scopus
- L. G. Fritsche, R. N. Fariss, D. Stambolian, G. R. Abecasis, C. A. Curcio, and A. Swaroop, “Age-related macular degeneration: genetics and biology coming together,” Annual Review of Genomics and Human Genetics, vol. 15, pp. 151–171, 2014. View at Publisher · View at Google Scholar · View at Scopus
- K. Lai and G. Landa, “Current choice of treatments for neovascular AMD,” Expert Review of Clinical Pharmacology, vol. 8, no. 1, pp. 135–140, 2015. View at Publisher · View at Google Scholar · View at Scopus
- T. Y. Wong, G. Liew, and P. Mitchell, “Clinical update: new treatments for age-related macular degeneration,” Lancet, vol. 370, no. 9583, pp. 204–206, 2007. View at Publisher · View at Google Scholar · View at Scopus
- B. M. Kevany and K. Palczewski, “Phagocytosis of retinal rod and cone photoreceptors,” Physiology, vol. 25, no. 1, pp. 8–15, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. G. Fritsche, W. Igl, J. N. Bailey et al., “A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants,” Nature Genetics, vol. 48, no. 2, pp. 134–143, 2016. View at Google Scholar
- M. E. Pennesi, M. Neuringer, and R. J. Courtney, “Animal models of age related macular degeneration,” Molecular Aspects of Medicine, vol. 33, no. 4, pp. 487–509, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. C. Khan, H. Shahid, D. A. Thurlby et al., “Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight,” British Journal of Ophthalmology, vol. 90, no. 1, pp. 29–32, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. C. Khan, D. A. Thurlby, H. Shahid et al., “Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation,” British Journal of Ophthalmology, vol. 90, no. 1, pp. 75–80, 2006. View at Publisher · View at Google Scholar · View at Scopus
- K. V. Chalam, V. Khetpal, R. Rusovici, and S. Balaiya, “A review: role of ultraviolet radiation in age-related macular degeneration,” Eye and Contact Lens, vol. 37, no. 4, pp. 225–232, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Balaiya, R. K. Murthy, V. S. Brar, and K. V. Chalam, “Evaluation of ultraviolet light toxicity on cultured retinal pigment epithelial and retinal ganglion cells,” Clinical Ophthalmology, vol. 4, no. 1, pp. 33–39, 2010. View at Google Scholar · View at Scopus
- B. Vojniković, D. Vojniković, and L. Brčić, “Histopathological analysis of UV-B irradiated retina by Cavia Coba'ya and with protection of transmission light λ 550-600 nm,” Collegium Antropologicum, vol. 31, supplement 1, pp. 29–31, 2007. View at Google Scholar · View at Scopus
- B. Vojniković and D. Vojniković, “Benedictine Monastery on the Island of Rab hides the mystery of sunlight influence on development of macular degeneration (AMD). Is a harmful sunligh, risk factor or cause of macular degeneration?” Collegium Antropologicum, vol. 34, no. 2, pp. 5–8, 2010. View at Google Scholar · View at Scopus
- M. C. Hollander, G. M. Blumenthal, and P. A. Dennis, “PTEN loss in the continuum of common cancers, rare syndromes and mouse models,” Nature Reviews Cancer, vol. 11, no. 4, pp. 289–301, 2011. View at Publisher · View at Google Scholar · View at Scopus
- X. Wang, H. Huang, and K. H. Young, “The PTEN tumor suppressor gene and its role in lymphoma pathogenesis,” Aging, vol. 7, no. 12, pp. 1032–1049, 2015. View at Publisher · View at Google Scholar · View at Scopus
- M. Ming, L. Feng, C. R. Shea et al., “PTEN positively regulates UVB-induced DNA damage repair,” Cancer Research, vol. 71, no. 15, pp. 5287–5295, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. López-Sánchez, E. Francés-Muñoz, J. L. Menezo, and M. D. Pinazo-Durán, “Optic nerve alterations in PTEN +/- mice,” European Journal of Ophthalmology, vol. 16, no. 3, pp. 440–445, 2006. View at Google Scholar · View at Scopus
- W. K. Jin, H. K. Kyung, P. Burrola, T. W. Mak, and G. Lemke, “Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium,” Genes and Development, vol. 22, no. 22, pp. 3147–3157, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Z. Chen, G. Jin, S. Lin et al., “DNA methyltransferase inhibitor CDA-II inhibits myogenic differentiation,” Biochemical and Biophysical Research Communications, vol. 422, no. 3, pp. 522–526, 2012. View at Publisher · View at Google Scholar · View at Scopus
- H. Shen, A. S. McElhinny, Y. Cao et al., “The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis,” Genes and Development, vol. 20, no. 6, pp. 675–688, 2006. View at Publisher · View at Google Scholar · View at Scopus
- S. Lin, L. Tian, H. Shen et al., “DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia,” Oncogene, vol. 32, no. 40, pp. 4845–4853, 2013. View at Publisher · View at Google Scholar · View at Scopus
- S. Yan, M. Sorrell, and Z. Berman, “Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress,” Cellular and Molecular Life Sciences, vol. 71, no. 20, pp. 3951–3967, 2014. View at Publisher · View at Google Scholar · View at Scopus
- N. McCabe, C. Hanna, S. M. Walker et al., “Mechanistic rationale to target PTEN-deficient tumor cells with inhibitors of the DNA damage response kinase ATM,” Cancer Research, vol. 75, no. 11, pp. 2159–2165, 2015. View at Publisher · View at Google Scholar · View at Scopus
- A. Chen, X. Huang, Z. Xue et al., “The role of p21 in Apoptosis, proliferation, cell cycle arrest, and antioxidant activity in UVB-irradiated human HaCaT keratinocytes,” Medical science monitor basic research, vol. 21, pp. 86–95, 2015. View at Publisher · View at Google Scholar · View at Scopus
- W.-W. Chou, K.-C. Chen, Y.-S. Wang, J.-Y. Wang, C.-L. Liang, and S.-H. H. Juo, “The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells,” Toxicology in Vitro, vol. 27, no. 6, pp. 1728–1736, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Y. Tendler, R. Pokroy, A. Panshin, and G. Weisinger, “P53 protein subcellular localization and apoptosis in rodent corneal epithelium cell culture following ultraviolet irradiation,” International Journal of Molecular Medicine, vol. 31, no. 3, pp. 540–546, 2013. View at Publisher · View at Google Scholar · View at Scopus
- K. L. H. Wu, C.-A. Wu, C.-W. Wu, S. H. H. Chan, A. Y. W. Chang, and J. Y. H. Chan, “Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats,” Antioxidants and Redox Signaling, vol. 18, no. 1, pp. 36–50, 2013. View at Publisher · View at Google Scholar · View at Scopus
- E. J. Lee, N. Kim, K. H. Kang, and J. W. Kim, “Phosphorylation/inactivation of PTEN by Akt-independent PI3K signaling in retinal pigment epithelium,” Biochemical and Biophysical Research Communications, vol. 414, no. 2, pp. 384–389, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J.-H. Chen, P. Zhang, W.-D. Chen et al., “ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells,” Autophagy, vol. 11, no. 2, pp. 239–252, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. Z. Nowak, “Age-related macular degeneration (AMD): pathogenesis and therapy,” Pharmacological Reports, vol. 58, no. 3, pp. 353–363, 2006. View at Google Scholar · View at Scopus