Markers of Alzheimer’s Disease in Primary Visual Cortex in Normal Aging in Mice

Figure 1

Double IF to detect Aβ42 (green channel) and p-Tau (red channel) in VC of 4 M and 25 M old mice. 15 um thick brain tissue sections of VC from mice were used. DAPI stain for nuclei (DAPI) and Merge are shown. Observe the intracellular accumulation, blood vessel deposition of Aβ42 peptide, and the increase of p-Tau signal in VC from 25 M old mice. Some tissues of mice show more Aβ42 deposition in blood vessels (two bottom last lines). Scale bar: 100 µm.