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BioMed Research International
Volume 2017 (2017), Article ID 3718615, 12 pages
Research Article

Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients

1Department of Anaesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
2Blood Bank University Hospital, Institute of Pathology, University of Louisville, Louisville, KY, USA
3Trauma Institute, Department of Surgery, University of Louisville, Louisville, KY, USA
4Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA
5Department of Outcomes Research, Anaesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA

Correspondence should be addressed to Detlef Obal

Received 26 October 2016; Revised 23 March 2017; Accepted 5 April 2017; Published 14 May 2017

Academic Editor: Nikolaos K. Kanakaris

Copyright © 2017 Alexander Bautista et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Prolonged storage of packed red blood cells (PRBCs) may increase morbidity and mortality, and patients having massive transfusion might be especially susceptible. We therefore tested the hypothesis that prolonged storage increases mortality in patients receiving massive transfusion after trauma or nontrauma surgery. Secondarily, we considered the extent to which storage effects differ for trauma and nontrauma surgery. Methods. We considered surgical patients given more than 10 units of PRBC within 24 hours and evaluated the relationship between mean PRBC storage duration and in-hospital mortality using multivariable logistic regression. Potential nonlinearities in the relationship were assessed via restricted cubic splines. The secondary hypothesis was evaluated by considering whether there was an interaction between the type of surgery (trauma versus nontrauma) and the effect of storage duration on outcomes. Results. 305 patients were given a total of 8,046 units of PRBCs, with duration ranging from 8 to 36 days (mean ± SD: days). The odds ratio [95% confidence interval (CI)] for in-hospital mortality corresponding to a one-day in mean PRBC storage duration was 0.99 (0.95, 1.03, ). The relationship did not differ for trauma and nontrauma patients (). Results were similar after adjusting for multiple potential confounders. Conclusions. Mortality after massive blood transfusion was no worse in patients transfused with PRBC stored for long periods. Trauma and nontrauma patients did not differ in their susceptibility to prolonged PRBC storage.