Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients

Table 4

Independent association between patient-specific mean red blood cell storage duration and secondary outcomes. All estimates are adjusted for age, renal disease, liver disease, initial blood pH, initial antiprothrombin time, and initial activated partial thromboplastin time. Estimates are reported with 95% confidence intervals in parentheses. Analyses reflect the same 259 patients that were included in the multivariable modeling for the primary outcome of in-hospital mortality. The reported measures of association reflect a one-day increase in patient mean red blood cell storage duration.

Outcome variable	Model type	Measure of association	Estimate	value
Duration of hospitalization (d)	Linear regression	Slope (95% CI)	−0.27 (−0.68, 0.13)	0.18
Duration of ICU stay (h)	Linear regression	Slope (95% CI)	−1.79 (−9.82, 6.24)	0.66
Duration of mechanical ventilation (h)	Linear regression	Slope (95% CI)	−0.91 (−7.13, 5.30)	0.77
Disseminated intravascular coagulopathy	Logistic regression	Odds ratio (95% CI)	0.98 (0.93, 1.03)	0.42
Shock	Logistic regression	Odds ratio (95% CI)	1.00 (0.95, 1.05)	0.97
Sepsis	Logistic regression	Odds ratio (95% CI)	0.96 (0.91, 1.02)	0.19
Wound infection	Logistic regression	Odds ratio (95% CI)	0.97 (0.93, 1.02)	0.28
Arrhythmia	Logistic regression	Odds ratio (95% CI)	0.98 (0.93, 1.02)	0.30
Myocardial infarction	Logistic regression	Odds ratio (95% CI)	1.09 (0.96, 1.25)	0.18
Acute respiratory distress syndrome	Logistic regression	Odds ratio (95% CI)	1.00 (0.96, 1.05)	>0.99
Acute kidney injury	Logistic regression	Odds ratio (95% CI)	1.00 (0.94, 1.05)	0.94
Pneumonia	Logistic regression	Odds ratio (95% CI)	0.99 (0.94, 1.03)	0.57
Pulmonary embolism	Logistic regression	Odds ratio (95% CI)	1.10 (0.96, 1.25)	0.15
Transfusion-related acute lung injury	Logistic regression	Odds ratio (95% CI)	1.06 (0.90, 1.26)	0.47