BioMed Research International

Research Article

Application of the Subtractive Genomics and Molecular Docking Analysis for the Identification of Novel Putative Drug Targets against Salmonella enterica subsp. enterica serovar Poona

Table 2

Essential proteins of Salmonella enterica subsp. enterica serovar Poona involved in unique metabolic pathways.
Associated pathwayGene(s) nameKEGG orthology (KO)
D-Alanine metabolismAlrK01775
Vancomycin resistancealr, murGK01775, K02563
Lipopolysaccharide biosynthesislpxA, lpxC, lpxD, lpxH, lpxB, lpxK, kdtA, lpxL, kdsB, kdsA, lpxM, waaQ, waaC, waaF, waaG, waaJ,K00677, K02535, K02536, K03269, K00748, K00912, K02527, K02517, K00979, K01627, K02560, K02849, K02841, K02843, K02844, K03279,
Cationic antimicrobial peptide (CAMP) resistancelpxA, tolC, phoQ, arnT, pmrK, acrB, mexB, adeJ, smeE, mtrD, cmeBK00677, K12340, K07637, K07264, K18138
Peptidoglycan biosynthesismurA, murC, murD, murF, mraY, murG, murJK00790, K01924, K01925, K01929, K01000, K02563, K03980, K05515
Cell cyclemurG, dnaA, dnaB, ftsZ, ftsQ, ftsAK02563, K02313, K02314, K03531, K03589, K03590
Bacterial secretion systemtolC, yscJ, sctJ, hrcJ, yscT, sctT, hrcT, secD, secY, secA, tatCK12340, K03222, K03228, K03072, K03076, K03070, K03118
Two-component systemtolC, phoQ, envZ, ompR, ompF, rcsB, dnaA,glnL, ntrB,cheB, pagOK12340, K07637, K07638, K07659, K09476, K07687, K02313, K07708, K03412, K07790
Protein exportsecD, secY, secA, tatCK03072, K03076, K03070, K03118
DNA replicationdnaBK02314
Bacterial chemotaxischeBK03412