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BioMed Research International
Volume 2017, Article ID 3793679, 6 pages
Research Article

Home Remodeling and Food Allergy Interact Synergistically to Increase the Risk of Atopic Dermatitis

1Department of Pediatrics, Graduate School, Kyung Hee University, Seoul, Republic of Korea
2Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
3Department of Pediatrics, Haeundae Paik Hospital, Inje University School of Medicine, Busan, Republic of Korea
4Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea

Correspondence should be addressed to Young-Ho Jung; moc.liamg@79gnujohgnuoy

Received 18 April 2017; Accepted 13 August 2017; Published 20 September 2017

Academic Editor: Marzia Caproni

Copyright © 2017 Won Seok Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The purpose of this study was to investigate the effects of home remodeling and food allergy (FA) on the development of atopic dermatitis (AD) in children. Methods. The Modified International Study of Asthma and Allergies in Childhood questionnaire was used to survey 4,111 children recruited from 3 kindergartens and 6 elementary schools from Seongnam, Korea. Participants’ parents agreed for them to participate in physical examinations, skin prick tests, and blood tests. Results. Home remodeling in the past 12 months (adjusted odds ratio [aOR] 3.40, ), lifetime diagnosis of FA (aOR 3.95, ), parental history of AD (aOR 2.67, ), and FA (aOR 2.35, ) were independent risk factors for lifetime diagnosis of AD ever. When history of home remodeling and FA were combined, the risk for moderate-to-severe AD by scoring atopic dermatitis (SCORAD) score increased (aOR, 7.19, , P for interaction = 0.034). Conclusion. Home remodeling, lifetime diagnosis of FA, parental history of AD, and parental history of FA were independent risk factors for AD. In addition, we observed a synergistic interaction between home remodeling and FA in the risk of moderate-to-severe AD.