Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone
Table 3
Univariate Cox regression survival analysis for all CRC patients undergoing surgery ().
Variables
OS
DFS
HR
95% CI
value
HR
95% CI
value
Age (≥65 versus <65)
1.469
0.596–3.622
0.404
1.405
0.660–2.991
0.378
Gender (male versus female)
1.952
0.703–5.424
0.191
1.692
0.740–3.865
0.212
Smoking
2.745
0.798–9.451
0.109
1.953
0.587–6.493
0.275
Family history
1.618
0.372–7.040
0.521
1.755
0.527–5.844
0.360
Cancer site
1.264
0.477–3.345
0.637
1.370
0.612–3.064
0.444
Histologic class
1.492
0.199–11.204
0.698
1.059
0.143–7.813
0.956
Differentiation
21.018
0–3707867.689
0.621
0.697
0.094–5.146
0.723
Tumor stage
4.491
1.308–15.418
0.017
3.049
1.231–7.557
0.016
Tumor size (≥5 cm versus <5 cm)
1.923
0.634–5.827
0.248
2.069
0.833–5.141
0.117
Fib (≥3.30 g/mL versus <3.30 g/mL)
1.092
0.429–2.777
0.853
1.263
0.567–2.812
0.568
RBC
≥4.43 versus <4.43 (×1012/mL)
1.460
0.593–3.596
0.410
1.538
0.723–3.275
0.264
PLR (≥113.5 versus <113.5)
2.656
0.881–8.010
0.083
2.048
0.865–4.846
0.103
NLR (≥2.43 versus <2.43)
3.193
1.213–8.405
0.019
2.582
1.182–5.644
0.017
CEA (≥5 ng/mL versus <5 ng/mL)
4.351
1.645–11.509
0.003
4.023
1.803–8.974
0.001
CA199
≥7.42 U/mL versus <5 U/mL
2.496
0.828–7.520
0.104
1.602
0.701–3.660
0.264
AC = adenocarcinoma; NAC = nonadenocarcinoma; Fib = fibrinogen; RBC = red blood cell; PLR = platelet-to-lymphocyte ratio; NLR = neutrophil-to-lymphocyte ratio; CEA = carcinoembryonic antigen; CA199 = carbohydrate antigen 199; COCN = combination of CEA and NLR; HR = hazard ratio; OS = overall survival; DFS = disease-free survival.
