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BioMed Research International
Volume 2017, Article ID 3906032, 10 pages
https://doi.org/10.1155/2017/3906032
Research Article

Effects of Target Temperature Management on the Outcome of Septic Patients with Fever

1Intensive Care Unit, Taicang Affiliated Hospital of Soochow University, Taicang 215400, China
2Intensive Care Unit, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China

Correspondence should be addressed to Lijun Liu; moc.anis@zsuilnujil

Received 8 August 2017; Accepted 8 October 2017; Published 12 November 2017

Academic Editor: Hideo Inaba

Copyright © 2017 Ye Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To investigate the effects of target temperature management on hemodynamic changes, inflammatory and immune factors, and clinical outcomes of sepsis patients with fever. Methods. Patients diagnosed with sepsis with a core temperature of ≥39°C were randomly divided into two groups: a low-temperature group (LT group: 36.5°C–38°C) and a high-temperature group (HT group: 38.5°C–39.5°C). A target core temperature was achieved within 6 hrs posttreatment and maintained for 24 hrs. Then, the hemodynamic changes, inflammatory and immune factors, and clinical outcomes were evaluated. Results. Compared with the HT group, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) showed a significant decrease in the LT group (). In contrast, IL-4 and IL-10 were higher in the LT group than in the HT group (). The CD4-T lymphocyte (CD4+), CD8-T lymphocyte (CD8+), and monocytic human leukocyte antigen-DR (mHLA-DR) in the LT group were higher than in the HT group (). The ICU stay and the anti-infection treatment costs were higher in the LT group (). Conclusion. Low-temperature management of patients resulted in a low level of proinflammatory cytokines. Excessive temperature control in sepsis patients with fever may be harmful.