Review Article
Genetic Epidemiology of Type 2 Diabetes in Mexican Mestizos
Table 2
Analysis of SNPs studied by two or more groups in Mexican mestizos.
| Gene | dbSNP loc | Cases (allele) | Controls (allele) | Risk allele frequency (%) | OR (95% CI) | value | Reference | Cases | Controls |
| CAPN10 | rs3792267 | 1086 | 928 | 29.5 | 28.7 | 1.06 (0.87–1.29) | 0.56 | [11–13] | CAPN10 | rs3842570 | 772 | 656 | 61.7 | 62.5 | 0.96 (0.78–1.20) | 0.74 | [11, 13, 14] | CAPN10 | rs5030952 | 686 | 530 | 19.0 | 18.3 | 1.04 (0.78–1.40) | 0.78 | [11, 13] | CDKAL1 | rs7754840 | 3092 | 3074 | 31.4 | 29.1 | 1.12 (1.00–1.25) | 0.044 | [8, 10] | HHEX | rs1111875 | 2974 | 2448 | 62.8 | 61.7 | 1.05 (0.94–1.17) | 0.43 | [8, 17] | IRS1 | rs1801278 | 2326 | 2380 | 6.6 | 2.8 | 2.45 (1.83–3.28) | <0.0001 | [12, 19] | PPARG | rs1801282 | 3492 | 3472 | 87.3 | 86.7 | 1.05 (0.91–1.21) | 0.51 | [8, 12] | SLC30A4 | rs13266634 | 2964 | 2448 | 76.3 | 73.0 | 1.19 (1.05–1.35) | 0.005 | [8, 17] | TCF7L2 | rs7903146 | 3740 | 3042 | 17.8 | 14.1 | 1.32 (1.16–1.50) | <0.0001 | [8, 12, 22] | TCF7L2 | rs12255372 | 2476 | 2586 | 18.3 | 11.6 | 1.40 (1.19–1.65) | <0.0001 | [12, 22] | TNF-α | rs1800629 | 810 | 1560 | 11.5 | 6.2 | 1.96 (1.45–2.64) | <0.0001 | [20, 24, 25] |
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’ correction chi-square test.
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