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BioMed Research International
Volume 2017, Article ID 3980972, 8 pages
Research Article

Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice

1School of Life Science, Shanxi University, Taiyuan 030006, China
2Institute of Biotechnology, Shanxi University, Taiyuan 030006, China

Correspondence should be addressed to Xinghua Wang; nc.ude.uxs@gnawhx and Yukun Yang; nc.ude.uxs@nukuygnay

Received 6 June 2017; Accepted 13 September 2017; Published 30 October 2017

Academic Editor: Yi-Ping Liu

Copyright © 2017 Xinghua Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Detailed safety assessment of sodium selenite and bioselenium (bio-Se) was conducted and the results were compared and discussed for the purpose of assessing safety of bio-Se for use in food applications. In this work, acute toxicity studies, micronucleus test, and sperm aberration study in mice, 30-day feeding test of mice, were conducted to evaluate the toxicity of bio-Se obtained from yeast with different fermentation time (transformative time: one month, three months, and six months), and the results were compared with that of inorganic Se (sodium selenite). LD50 of sodium selenite was calculated to be 21.17 mg/kg. LD50 of bio-Se obtained from yeast with different fermentation time was calculated to be 740.2 mg/kg, 915.3 mg/kg, and 1179.0 mg/kg, respectively. In the genotoxicity test, bio-Se did not show cytotoxicity and genotoxicity of mice while sodium selenite at all dose groups was significantly different from the negative group. In the 30-day subchronic oral toxicity study, sodium selenite may slow down the growth of the mice and lead to organic damage to some extent. Bio-Se had facilitated effect towards the body weight of the mice and had no significant effect on the shape and function of the important organs of the mice.