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BioMed Research International
Volume 2017, Article ID 4051763, 8 pages
https://doi.org/10.1155/2017/4051763
Research Article

Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

1Office of Research and Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan
4Invasive Cardiac Laboratory, Tan Tock Seng Hospital, Singapore 308433
5Department of Chemistry, Chung Yuan Christian University, Taoyuan 320, Taiwan
6Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan
7Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
11Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan
12Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
14Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan

Correspondence should be addressed to Yu-Chang Tyan; wt.ude.umk@naytcy

Received 21 September 2016; Accepted 5 December 2016; Published 3 January 2017

Academic Editor: Yue W. Huang

Copyright © 2017 Shih-Cheng Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.