Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance

Table 3

ncRNAs affecting both cardiovascular diseases and insulin resistance.

ncRNA	Insulin resistance effect	Cardiovascular effect	Description
miR-34a	Hyperglycemia	Impaired angiogenesis	miR-34a dependent gene regulatory system governs SIRT1 levels and eNOS modifications, both of which affect the two related disease conditions [17].
miR-134	Diabetes mellitus	Microvascular structure formation and reduced cell migration	Highly expressed in patients with the two disease conditions [17].
miR-130a	Diabetes mellitus	Endothelial Progenitor Cell (EPCs) regulation	Diabetes mellitus patients show decreased proliferation, colony formation, and migration but increased apoptosis in EPCs [17].
miR-24	High glucose levels	VSMC pathology	miR-24 targets genes causing high glucose induced cell proliferation and migration [17].
miR-504	Diabetes mellitus	VSMC dysfunction	Upregulation causing both conditions in patients [17].