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BioMed Research International
Volume 2017, Article ID 4269435, 7 pages
Research Article

Comparison of the Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation with That of Theta Burst Stimulation on Upper Limb Motor Function in Poststroke Patients

1Shimizu Hospital, Kurayoshi-City, Tottori, Japan
2Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan

Correspondence should be addressed to Naoki Yamada; pj.oc.oohay@129210alem and Masahiro Abo;

Received 8 June 2017; Accepted 19 July 2017; Published 5 November 2017

Academic Editor: Noman Naseer

Copyright © 2017 Takahiro Kondo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The purpose of this study was to evaluate the difference between the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) and that of continuous theta burst stimulation (cTBS), when each is combined with intensive occupational therapy (OT), in poststroke patients with upper limb hemiparesis. Materials and Methods. The study subjects were 103 poststroke patients with upper limb hemiparesis, who were divided into two groups: the LF-rTMS group () and the cTBS group (three pulse bursts at 50 Hz) (). Each subject received 12 sessions of repetitive transcranial magnetic stimulation of 2,400 pulses applied to the nonlesional hemisphere and 240-min intensive OT (two 60-min one-to-one training sessions and two 60-min self-training exercises) daily for 15 days. Motor function was evaluated using the Fugl-Meyer Assessment (FMA) and the performance time of the Wolf motor function test (WMFT) was determined on the days of admission and discharge. Results. Both groups showed a significant increase in the FMA score and a short log performance time of the WMFT (), but the increase in the FMA score was higher in the LF-rTMS group than the cTBS group (). Conclusion. We recommend the use of 2400 pulses of LF-rTMS/OT for 2 weeks as treatment for hemiparetic patients.