TY - JOUR A2 - Baynes, Ronald E. AU - Jung, In Young AU - Kim, Jung Ju AU - Lee, Se Ju AU - Kim, Jinnam AU - Seong, Hye AU - Jeong, Wooyong AU - Choi, Heun AU - Jeong, Su Jin AU - Ku, Nam Su AU - Han, Sang Hoon AU - Choi, Jun Yong AU - Song, Young Goo AU - Park, Jung Won AU - Kim, June Myung PY - 2017 DA - 2017/12/31 TI - Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea SP - 4304973 VL - 2017 AB - Background. Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea. Methods. This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated. Results. 1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%). Totally, 44 (3.4%) patients experienced serious ADRs. Penicillin and quinolones were the most common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%). The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%). Conclusion. Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom. SN - 2314-6133 UR - https://doi.org/10.1155/2017/4304973 DO - 10.1155/2017/4304973 JF - BioMed Research International PB - Hindawi KW - ER -