TY - JOUR
A2 - Baynes, Ronald E.
AU - Jung, In Young
AU - Kim, Jung Ju
AU - Lee, Se Ju
AU - Kim, Jinnam
AU - Seong, Hye
AU - Jeong, Wooyong
AU - Choi, Heun
AU - Jeong, Su Jin
AU - Ku, Nam Su
AU - Han, Sang Hoon
AU - Choi, Jun Yong
AU - Song, Young Goo
AU - Park, Jung Won
AU - Kim, June Myung
PY - 2017
DA - 2017/12/31
TI - Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea
SP - 4304973
VL - 2017
AB - Background. Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea. Methods. This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated. Results. 1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%). Totally, 44 (3.4%) patients experienced serious ADRs. Penicillin and quinolones were the most common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%). The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%). Conclusion. Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom.
SN - 2314-6133
UR - https://doi.org/10.1155/2017/4304973
DO - 10.1155/2017/4304973
JF - BioMed Research International
PB - Hindawi
KW -
ER -