Fungicidal, Corrosive, and Mutational Effects of Polyhexamethylene Biguanide Combined with 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione

Table 4

Effects of PB on mutant frequency of L5178Y cells.

Groups	+S9					Groups	−S9
	RSG; (%)	PE0; (%)	PE2; (%)	RS; (%)	MF; (10^−6)		RSG; (%)	PE0; (%)	PE2; (%)	RS; (%)	MF; (10^−6)
1	74.1	61.3	66.74	73.49	141.4	1	78.2	53.94	56.3	78.11	159.2
2	60.2	51.67	63.96	70.43	140.1	2	72.2	43.32	47.36	65.7	95.2
3	46.3	34.25	32.58	35.88	86.4	3	59.5	37.72	45.31	62.86	62.1
4	29.9	27.83	26.33	28.99	122.8	4	17.7	23.42	27.83	38.61	71.6
H2O	100	75.76	90.82	100	138.9	H2O	100	64.43	72.08	100	171.5
CP	30.1	38.93	37.95	41.79	380.9	MMS	34.0	26.03	31.81	44.13	454.4

Notes. Groups 1–4: 0.8 μg/mL PHMB + 0.8 μg/mL BCDMH, 1.6 μg/mL PHMB + 1.6 μg/mL BCDMH, 3.2 μg/mL PHMB + 3.2 μg/mL BCDMH, and 6.4 μg/mL PHMB + 6.4 μg/mL BCDMH, respectively (final concentration). CP: 3 μg/mL cyclophosphamide, MMS: 3 μg/mL cyclophosphamide, and 10 μg/mL methyl methanesulfonate. .