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BioMed Research International
Volume 2017, Article ID 4368474, 11 pages
https://doi.org/10.1155/2017/4368474
Review Article

Association between Antihypertensive Drug Use and the Incidence of Cognitive Decline and Dementia: A Meta-Analysis of Prospective Cohort Studies

1Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730030, China
2Department of Urology, Lanzhou University Second Hospital, Lanzhou 730030, China
3Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China

Correspondence should be addressed to Bingren Gao; moc.anis@oagnergnib

Received 8 May 2017; Revised 28 June 2017; Accepted 27 July 2017; Published 28 September 2017

Academic Editor: Cristiano Capurso

Copyright © 2017 Guangli Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Antihypertensive drug use is inconsistently associated with the risk of dementia, Alzheimer’s disease, cognitive impairment, and cognitive decline. Therefore, we conducted a meta-analysis of available prospective cohort studies to summarize the evidence on the strength of these relationships. Methods. Three electronic databases including MedLine, Embase, and the Cochrane Library were searched to identify studies from inception to April 2017. Only prospective cohort studies that reported effect estimates with corresponding 95% confidence intervals (CIs) of dementia, Alzheimer’s disease, cognitive impairment, and cognitive decline for antihypertensive drug use versus not using antihypertensive drugs were included. Results. We included 10 prospective cohort studies reporting data on 30,895 individuals. Overall, participants who received antihypertensive drugs had lower incidence of dementia (relative risk [RR]: 0.86; 95% CI: 0.75–0.99; ), while there was no significant effect on the incidence of Alzheimer’s disease (RR: 0.83; 95% CI: 0.64–1.09; ), cognitive impairment (RR: 0.89; 95% CI: 0.57–1.38; ), and cognitive decline (RR: 1.11; 95% CI: 0.86–1.43; ). Further, the incidence of Alzheimer’s disease might be affected by antihypertensive drug use in participants with specific characteristics. Conclusions. Antihypertensive drug use was associated with a significantly reduced risk of dementia, but not with the risk of Alzheimer’s disease, cognitive impairment, and cognitive decline.